Dr Stephen Getting

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Principal Lecturer

Life Sciences

(United Kingdom) +44 20 7911 5000 ext 64100
115 New Cavendish Street
London
GB
W1W 6UW
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About me

Dr Stephen J. Getting is Principal Lecturer in Pharmacology at the University of Westminster and Co-Course leader BSc Pharmacology and Physiology. Dr Getting has over 25 years’ experience in unraveling the anti-inflammatory effects of novel endogenous peptides in a model of arthritis, cardiovascular disease, asthma and neuroinflammation.  Graduating from The School of Pharmacy, UCL and completing a PhD in Immunopharmacology at Bart’s and Royal London Medical Schools. He has worked in Industry (Wellcome Research Laboratories), WHRI Contract Research, and Universities including Monash Medical School, Australia, Kings College London, Imperial College London and University of Naples, Italy, where he held a fellowship. This has allowed for a multi-discipline research career with over 150 articles published (including 60 full publications), being awarded the Gordon Van Arman Award for Excellence in Inflammation Research from the Inflammation Research Association and Derek Willoughby Young Investigator Award, World Congress on Inflammation. He has acted as a PhD supervisor to 12 students and undertaken PhD/Chaired Examinations at QMUL, University of Copenhagen and University of Westminster. He has served on the Schools Research Committee and was the research lead for Cell Communication Research Cluster and returned for RAE/REF since 2008.

Specialties: Dr Getting is an experienced researcher and educator, with a strong track record in delivering research outcomes, supervision and educating students in pharmacological research. He has strong leadership ensuring goals are met and people reach their full potential, with publications in Nature Medicine, J. Ex. Med, British Journal of Pharmacology, Journal of Immunology, Arthritis and Rheumatism, TIPS and FEBS Letters, FASEB J.

Teaching

I am a Principal Lecturer in Pharmacology and co-course leader for BSc Pharmacology and Physiology. previous roles have included divisional coordinator for Biochemistry, Pharmacology and Applied Biology from 2016 to Jan 2019 and PhD admissions tutor from 2014-2018. I hold a postgraduate certificate in education and fellowship of the Higher Education Academy. He has acted as an External Advisor for re validation of the Pharmacology Degree at University of East London and External Examiner at University of East London, Imperial College and Anglia Ruskin University.

I deliver pharmacology, physiology, toxicology, drug discovery teaching and project supervision at undergraduate and postgraduate level.

Currently I am the module leader for the second year pharmacology module Experimental Pharmacology and Therapeutics and two final year modules, Drug Discovery: Bench to Bedside and UG project module. Within these modules we aim to allow students to become autonomous learners and develop their research skills, through critically evaluating research articles, researching novel techniques and identifying new lines of research to enhance these studies and identifying the skills required for the workplace. Utilization of research and technology within my teaching allows the students to develop core translatable skills designed to enhance their learning and future employability.

In addition to these module leaderships I provide teaching, practical and project supervision across all levels within the College including supervision of PhD students.

He is a pivotal member of the Pharmacology team who have a 85% NSS satisfaction score (The Uni guide)

Research

Current research 

I am a pharmacologist interested in unraveling the biological effects of endogenous modulators and natural products on the host inflammatory response and cell protection and have supervised 12 students to completion of their PhD. My main interest is understanding the role played by the melanocortin peptides and natural products. The aim of this research is to understand their mechanism of action of these compounds and identification of the target receptors for pharmacological manipulation and subsequent disease treatment. Understanding how these naturally occurring anti-inflammatory agents exhibit a dual mechanism of action i.e. an early phase inhibition of cytokine release and a late induction of pro-resolving pathways is an exciting development. This research will hopefully lead to development of novel therapeutics to treat some of the biggest debilitating diseases that we face including arthritis and cerebral ischaemia. At present my main research areas involve looking at the biological effects of these peptides and natural products in human osteoarthritic cell-lines and in models of neuroinflammation and neuroprotection.

Research group 

Pathobiology Exosome Research Group

Research students 

Vedia Can, Sirisha Yerramalli, Dina Ahmed and Isabella Cooper

Research projects 

Investigation into the role that melanocortin and other endogenous anti-inflammatory peptides play in rheumatoid and osteoarthritis determining their chondroprotective and anti-inflammatory role. In addition projects are looking at the role of these endogenous peptides in cerebral ischaemia and neuroprotection.

Transferable skills include 

Experimental design and implementation, statistical analysis, cell culture, biochemical assays, PCR and western blotting.

Projects areas include 

Rheumatoid and osteoarthritis (chondroprotection) and cerebral ischaemia (neuroprotection)

Membership of professional bodies

  • British Pharmacological Society
  • Fellow of the Higher Education Academy

Selected Publications

Zhenqiang Yao 1Stephen J Getting 2Ian C Locke (2021). Regulation of TNF-Induced Osteoclast Differentiation. Cells. 2021 Dec 31;11(1):132. doi: 10.3390/cells11010132.

Edward S WicksteadMurray A IrvingStephen J GettingSimon McArthur (2022). Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. FEBS J. 2022 Apr;289(7):1801-1822. doi: 10.1111/febs.15861. 

Wickstead, E.S., Irving, M.A., Getting, S.J. and McArthur, S. (2021). Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. The FEBS Journal. Advanced online publication. https://doi.org/10.1111/febs.15861 

Can, V., Locke, I.C., Kaneva, M., Kerrigan, M.J.P., Merlino, F., De Pascale, C., Grieco, P. and Getting, S.J. (2020). Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated. Eur J. Pharmacol (872); 172971 

Wickstead, E. Getting, S.J., Biggs, C.S. and McArthur, S. (2020). Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Oxidative Medicine and Cellular Longevity. 2139192. https://doi.org/10.1155/2020/2139192

Momen-Heravi FGetting SJMoschos SA. (2018) Extracellular vesicles and their nucleic acids for biomarker discovery. Pharmacol Ther. 2018 Dec;192:170-187. doi: 10.1016/j.pharmthera.2018.08.002

Rossi S,Maisto R,Gesualdo C,Trotta MC,Ferraraccio F,Kaneva MK,Getting SJ,Surace E,Testa F,Simonelli F,Grieco P,Merlino F,Perretti M,D'Amico M,Di Filippo C. (2016) Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Mediators Inflamm. Published online 2016 Jan 12. doi:  10.1155/2016/7368389

Holloway PM,Durrenberger PF, Trutschl M,Cvek U,Cooper D,Orr AW,Perretti M,Getting SJ,Gavins FN. Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. Arterioscler Thromb Vasc Biol. 2015 Sep; 35(9): 1936–1944. Published online 2015 Jun 25. doi: 10.1161/ATVBAHA.115.305348

Magdalena K. Kaneva, Mark J.P. Kerrigan, Paolo Grieco, G. Paul Curley, Ian C. Locke and Stephen J. Getting (2014). Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Biochem Pharmacol: S0006-2952(14)00492-4. doi: 10.1016/j.bcp.2014.08.019. [Epub ahead of print] 

Intekhab-Alam, NY., White, OB., Getting, SJ., Petsa, A., Knight, RA., Chowdrey, HS., Townsend, PA., Lawerence, KM. and Locke, IC. (2013) Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis? Cell Death and Disease 4:e717

Gavins, FN., Hughes, EL., Buss, NA., Holloway, PM., Getting, SJ., Buckingham, JC (2012). Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1- FPR2/ALX anti-inflammatory system. FASEB J. 26(12): 4977-89. 

Magdalena K. Kaneva, Mark J.P. Kerrigan, Paolo Grieco, G. Paul Curley, Ian C. Locke and Stephen J. Getting (2012). Anti-Inflammatory effects of Melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes. Br J. Pharmacol 167(1) 67-79.

Holloway, PM., Smith, HK., Renshaw, D., Flower RJ., Getting SJ. and Gavins FN (2011). Targeting the melanocortin receptor system for anti-stroke therapy. Trends Pharmacol Sci 32(2): 90-98. 

Patel, HB., Bombardieri, M., Sampaio, A., D'Acuquisto, F., Gray, M., Grieco, P., Getting, S.J., Pitzalis, C. and Perretti, M. (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. Faseb J. 24(12): 4835-4843.

Publications

For details of all my research outputs, visit my WestminsterResearch profile.